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SOURCE Aspect Imaging
Novel system for high-throughput 3D digital imaging of pre-clinical
phenotypes launched at 52nd Society of Toxicology Annual Meeting 2013
SAN ANTONIO, TX, March 11, 2013 /PRNewswire/ - Aspect Imaging, the world
leading developer of high-performance compact magnets, today announced
the launch of its M2™ 3D MR-based histology system for in vivo and ex vivo toxicological imaging. The announcement was made at the 52nd Society of Toxicology Annual Meeting in San Antonio, Texas, March 10
-14, 2013, the largest annual meeting of toxicology and pathology
professionals.
The M2 3D MR-based histology system is a compact, high-performance MRI
instrument for high-throughput in vivo and ex vivo imaging of pre-clinical samples. The M2 provides all of the benefits of
MRI including high-resolution 3D images of anatomical morphology and
quantitative information of disease progression and regression. The
M2's novel design is based on an innovative permanent magnet design
meaning that the magnet does not require costly cryogens to cool and
maintain its magnetic field. It is also "self-shielded" and
consequently there is virtually no external fringe magnetic field. As a
result, the compact MRI can be placed in most locations in a research
lab and it does not require any special infrastructure. Aspect Imaging
also provides a complete line of PhenoQuant™ contrast agents which further enhances the MR-based imaging of fixed
samples and in vivo models.
"Conventional MRI is a gold standard for 3D pre-clinical imaging but its
inherent cost and complexity have made it inaccessible to the
toxicologist", says Uri Rapoport, Aspect Imaging's Founder and CEO.
"With the launch of our M2 3D MR-based histology system, research labs
can now leverage the power of 3D morphological imaging to compliment
and guide their traditional histology and do so with a system that is
affordable, easy to install, easy to operate by a technician with no
imaging experience and with the benefit of high-resolution digital
images."
A detailed study of the M2™ 3D MR-based Histology System - "3D MRI-Based Histology Using Compact, High-Resolution MRI" - is being presented as a late-breaking poster at the SOT Scientific
Sessions. "3D MR-based histology of fixed tissue specimens is gaining
recognition as a technique to provide complimentary information to
conventional histological techniques, as numerous digital slices from
any plane of the intact sample can be acquired in 3D, quantified and
then followed-up by conventional histology", says Dr. Yael
Schiffenbauer, the presenter and scientific lead on the research study.
"This study investigated the capabilities of this new compact 3D
MR-based histology platform as a complementary method in toxicology
studies. The study validated mouse models of acute kidney injury (AKI)
as quantified by in vivo MRI, ex vivo MR-based histology, and conventional Histology and immunostaining. The
high correlation between conventional histology and this novel platform
shows the strong promise for using 3D MR-based histology to guide
conventional histology in research and drug development toxicological
settings".
The M2™ 3D MR-based histology system is being demonstrated at ToxExpo
2013, the commercial exhibition of the SOT Annual Meeting, in Aspect
Imaging's booth #1158. The scientific poster, "3D MRI-Based Histology Using Compact, High-Resolution MRI", Poster #2634, Board #330, will be presented in the SOT Scientific
Sessions from 8:30 am - noon on Thursday, March 14, 2013 at the Henry
B. Gonzalez Convention Center in San Antonio, Texas.
About Aspect Imaging:
Aspect Imaging (www.aspectimaging.com) is the world's leader in the design and development of high-performance
compact MRI imaging systems for pre-clinical, clinical and advanced
industrial applications. In the clinical market, Aspect Imaging has
multiple clinical programs underway including its system to provide
highly efficient just-in-place compact MRI for imaging of the wrist.
The system allows clinicians to harness the power and insights of MRI
but without the cost, complexity and technical burden of traditional
MRI systems. In the pre-clinical research market, Aspect supplies its
M2™ magnet, gradients and handling systems to Bruker for use in its
leading ICON™ compact MRI platform. Due to its high-performance M2
permanent magnet and suite of related products, the ICON enables
academic researchers and pharmaceutical companies to quantify their
research models quickly and reliably. Pre-clinically, Aspect's M2
system is also used for providing 3D MR-based Histology to compliment
and direct pathology and histology-based analysis as well as providing
the M2 platform to Mediso Medical Systems for use in its nanoScan®
integrated PET/MRI and SPECT/MRI systems. Aspect Imaging's novel
permanent magnets are also used in advanced industrial applications
including rheology where its MicroFlow™ platform can operate inline on
large-scale production lines for food processing, consumer products,
biofuels and other applications providing real-time, non-invasive and
quantitative read-outs for process and quality control.
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